Effect of centrally administered nitric oxide modulators in Brewer's yeast-induced nociception in rats.
Indian J Exp Biol
;
2000 Nov; 38(11): 1123-8
Artigo
em Inglês
| IMSEAR
| ID: sea-61265
ABSTRACT
Possible modulation of Brewer's yeast-induced nociception by centrally (icv) administered nitric oxide (NO) modulators, viz., NO synthase (NOS) inhibitors, NO precursor, donors, scavengers and co-administration of NO donor (SIN-1) with NOS inhibitor (L-NAME) and NO scavenger (Hb) was investigated in rats. Administration of NOS inhibitors and NO scavenger Hb increased the pain threshold capacity significantly, whereas NO donors SIN-1, SNP and NO precursor L-arginine were found to be hyperalgesic. D-arginine, the inactive isomer of L-arginine and methylene blue, inhibitor of soluble guanylate cyclase failed to alter the nociceptive behaviour in rats. Co-administration of SIN-1 with L-NAME and Hb found to increase the nociceptive threshold. The results indicate, that centrally administered NO modulators alter the nociceptive transmission induced by Brewer's yeast in rats.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Dor
/
Ratos
/
Saccharomyces cerevisiae
/
Masculino
/
Ratos Wistar
/
Limiar da Dor
/
Óxido Nítrico Sintase
/
Doadores de Óxido Nítrico
/
Inibidores Enzimáticos
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2000
Tipo de documento:
Artigo
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