Evaluation of vanillic acid analogues as a new class of antifilarial agents.
Indian J Exp Biol
;
1993 Oct; 31(10): 819-21
Artigo
em Inglês
| IMSEAR
| ID: sea-61329
ABSTRACT
A number of vanillic acid analogues (1-14) have been synthesised and evaluated against experimental filarial infections using cotton rats (Sigmodon hispidus) infected with Litomosoides carinii, a primary screening model, at a dose of 30 mg/kg, ip for 5 days. Of the 8 compounds tested, 4 (5,7, 11 and 12) exhibited high micro- and macro-filaricidal activity with sterilization of surviving female worms. Compounds 5, 7, 12 showed remarkable adulticidal action (> 80%). Sterilization of the female worms by compounds 11 and 12 was highly significant (80-100%).
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ácido Vanílico
/
Feminino
/
Masculino
/
Sigmodontinae
/
Avaliação Pré-Clínica de Medicamentos
/
Filaricidas
/
Filarioidea
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1993
Tipo de documento:
Artigo
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