Antiallergic activity of alkyl substituted pyrazolo[3, 4-d]pyrimidine (compound 88-765).
Indian J Exp Biol
;
1995 Jan; 33(1): 38-40
Artigo
em Inglês
| IMSEAR
| ID: sea-61471
ABSTRACT
Compound 88-765 (4-amino-6-methylthio-1-(2', 2'-diethoxyethyl)-1 H-pyrazolo[3, 4-d]pyrimidine) has shown potent antiallergic activity in experimental models. The compound inhibited the passive cutaneous anaphylaxis (PCA) reaction in rats in dose-dependent manner (5-100 mg/kg, po) by 47 to 87%. In mice it inhibited PCA by 78% at 50 mg/kg, po. It also inhibited mast cell degranulation of normal and passively sensitised rats induced by compound 48/80 and egg albumin, respectively. These effects of Compound 88-765 were comparable with that of disodium cromoglycate (DSCG). The results suggest that compound 88-765 possesses potent antiallergic activity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pirazóis
/
Pirimidinas
/
Ratos
/
Masculino
/
Anafilaxia Cutânea Passiva
/
Cromolina Sódica
/
Antialérgicos
/
Animais
/
Mastócitos
/
Camundongos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1995
Tipo de documento:
Artigo
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