Receptor-operated calcium-channels in isolated rabbit jejunum.
Indian J Exp Biol
;
1992 Feb; 30(2): 107-9
Artigo
em Inglês
| IMSEAR
| ID: sea-61500
ABSTRACT
Calcium channels were studied in isolated spontaneously rhythmic rabbit jejunum using the muscarinic agonist carbachol as stimulant. Carbachol failed to produce the characteristic phasic and tonic components of smooth muscle contractions. A variety of chemically distinct calcium antagonists, viz. bepridil, diltiazem, isradipine (PN 200-110), nifedipine, and verapamil, non-competitively inhibited the contractions. Diltiazem was most potent (-logIC50 = 8.30) and bepridil least potent (-logIC50 = 6.19) in inhibiting the contractions. The findings conclude with the presence of pharmacologically distinct receptor-operated calcium-channels, besides the potential-dependent calcium-channels, in the rabbit jejunum.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Coelhos
/
Carbacol
/
Bloqueadores dos Canais de Cálcio
/
Canais de Cálcio
/
Relação Dose-Resposta a Droga
/
Jejuno
/
Animais
/
Contração Muscular
/
Músculo Liso
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1992
Tipo de documento:
Artigo
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