Hepatic superoxide dismutase, catalase and lipid peroxidation products in Mastomys natalensis infected with Plasmodium berghei.

ABSTRACT

P. berghei infection in M. natalensis caused a significant reduction in the hepatic SOD and catalase activities. Cu-Zn SOD was more susceptible to infection than Mn SOD. The inhibition of enzyme activities was associated with marked increase in the levels of lipid peroxides, lipid hydroperoxides and conjugated dienes in infected M. natalensis. The alterations in the hepatic SOD, catalase and lipid peroxides are related with the severity of infection.