In vitro percutaneous absorption of verapamil.
Indian J Exp Biol
;
1996 May; 34(5): 475-7
Artigo
em Inglês
| IMSEAR
| ID: sea-61653
ABSTRACT
The in vitro percutaneous absorption of verapamil hydrochloride (VHCl) was investigated in order to assess its feasibility for transdermal development. The experiments were carried across mice and guinea pig skins using Keshary-Chien diffusion cell. The values of diffusion rate (J) and permeability coefficient (Kp) across guinea pig skin were lowered as compared to mouse skin. Increased drug concentration in donor compartment increased value of J but decreased value of Kp. Under similar conditions, values of J and Kp were lowered for dorsal skin as compared to abdominal skin, both for mice and guinea pig. The results indicate that verapamil can be administered transdermally.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pele
/
Administração Cutânea
/
Bloqueadores dos Canais de Cálcio
/
Verapamil
/
Cobaias
/
Animais
/
Camundongos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1996
Tipo de documento:
Artigo
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