Neovascularisation offers a new perspective to glutamine related therapy.
Indian J Exp Biol
;
2000 Jan; 38(1): 88-90
Artigo
em Inglês
| IMSEAR
| ID: sea-61666
ABSTRACT
Angiogenesis or the generation of new blood vessel, is an important factor in the growth of a solid tumor. Hence, it becomes a necessary parameter of any kind of therapeutic study. Glutamine is an essential nutrient of tumor tissue and glutamine related therapy involves clearance of circulatory glutamine by glutaminase. Therefore, using different murine solid tumor models, the present study was undertaken to find out whether the S-180 cell glutaminase has any effect on angiogenesis of solid tumor, or not. Result indicates that the purified S-180 cell glutaminase reduces tumor volume and restrict the generation of neo blood vessels. Therefore, it can be concluded that this enzyme may be an effective device against the cancer metastasis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Sarcoma 180
/
Masculino
/
Ensaios de Seleção de Medicamentos Antitumorais
/
Carcinógenos
/
Carcinoma de Ehrlich
/
Inibidores da Angiogênese
/
Glutaminase
/
Glutamina
/
Injeções Intraperitoneais
/
Animais
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2000
Tipo de documento:
Artigo
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