Protective effect of hesperidin on nicotine induced toxicity in rats.
Indian J Exp Biol
;
2007 Feb; 45(2): 194-202
Artigo
em Inglês
| IMSEAR
| ID: sea-61694
ABSTRACT
Nicotine administration (2.5 mg/kg of body weight, sc, 5 days a week for 22 weeks) enhanced lipid peroxidative indices (thiobarbituric acid reactive substances and hydroperoxides) accompanied by a significant increase in the marker enzymes alanine transaminase, aspartate transaminase, alkaline phosphatase and lactate dehydrogenase and elevated levels of cholesterol, triglycerides, phospholipids and free fatty acids in Wistar rats. There was a significant protection by hesperidin administration at different doses (25, 50, 75, 100 and 150 mg/kg body weight) in nicotine-treated rats. However, the effect of hesperidin was more significant at 25mg/kg dose. The results suggest that hesperidin exerts the protective effects by modulating the extent of lipid peroxidation. The results are supported by histopathological observations of lung, liver and kidney.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfolipídeos
/
Ratos
/
Triglicerídeos
/
Masculino
/
Peroxidação de Lipídeos
/
Distribuição Aleatória
/
Colesterol
/
Substâncias Reativas com Ácido Tiobarbitúrico
/
Ratos Wistar
/
Ácidos Graxos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2007
Tipo de documento:
Artigo
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