Cerebellar granule cell membranes and glutamate mediates transactivation of glutamine synthetase promoter.
Indian J Exp Biol
;
1997 Feb; 35(2): 123-7
Artigo
em Inglês
| IMSEAR
| ID: sea-61700
ABSTRACT
Potential region of glutamine synthetase promoter driving astrocyte-specific transactivation, mediated by cerebellar granule cell membrane and glutamate has been identified by deletion analysis of promoter and transient transfection. The promoter region from -420 to -765 was found to be potentially important for this transactivation. These results provided further evidence for importance of neuronal-glial and glutamate-glial interactions in regulation of glial gene expression.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Células Tumorais Cultivadas
/
Ativação Transcricional
/
Cerebelo
/
Astrócitos
/
Mutagênese Sítio-Dirigida
/
Regiões Promotoras Genéticas
/
Ácido Glutâmico
/
Grânulos Citoplasmáticos
/
Glutamato-Amônia Ligase
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1997
Tipo de documento:
Artigo
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