Effect of beta-adrenoceptor antagonists and some related drugs on maximal electroshock seizures in mice.
Indian J Exp Biol
;
1989 Feb; 27(2): 128-30
Artigo
em Inglês
| IMSEAR
| ID: sea-61776
ABSTRACT
(+/-) Propranolol (1-50 mg/kg), (+) propranolol (50 mg/kg) and pindolol (10-50 mg/kg) exhibited significant protective effects against MES (maximum electroshock seizures), whereas, timolol (1 mg/kg), the propranolol analog, UM-272 (1 and 10 mg/kg), and the beta-agonist, terbutaline (1 and 10 mg/kg) were ineffective. Cholinergic agents, physostigmine (0.01-1.0 mg/kg), and atropine (1 and 10 mg/kg), the serotonin antagonist, cyproheptadine (0.05 mg/kg), and the prostaglandin synthesis inhibitor, indomethacin (10 mg/kg), were also without effect on the MES extensor phase. Further, pretreatment of mice with terbutaline, atropine, cyproheptadine or indomethacin did not influence the anti-MES effect of propranolol to any significant extent. The results indicate that the observed anticonvulsant effects of beta-adrenoceptor antagonists are unrelated to noradrenergic or other central neurotransmitter systems and that a non-specific mechanism, probably a membrane stabilizing effect is involved.
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Índice:
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Assunto principal:
Fisostigmina
/
Atropina
/
Convulsões
/
Feminino
/
Masculino
/
Indometacina
/
Antagonistas Adrenérgicos beta
/
Ciproeptadina
/
Eletrochoque
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1989
Tipo de documento:
Artigo
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