Nuclear matrix bound DNA polymerase-beta in mouse fibrosarcoma: effect of gamma-radiation.
Indian J Exp Biol
;
1996 Sep; 34(9): 868-9
Artigo
em Inglês
| IMSEAR
| ID: sea-61803
ABSTRACT
Nuclear matrices isolated from the mouse fibrosarcoma tumour cells contain the eukaryotic replicative enzyme DNA polymerase-alpha and the presumptive repair enzyme DNA polymerase-beta. Exposure of tumors to various doses of gamma-radiation (1.95 to 6.5 Gy) causes a 2-fold increase in the levels of only DNA polymerase-beta in the nuclear matrix. The increase in the levels of this enzyme is not discernible if the matrices are isolated 24 hr after irradiation. The rise in the levels of the repair enzyme DNA polymerase-beta could be indicative of radiation stress response of the tumour cells and their repair ability.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Matriz Nuclear
/
DNA Polimerase I
/
Fibrossarcoma
/
Raios gama
/
Animais
/
Camundongos
/
Transplante de Neoplasias
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1996
Tipo de documento:
Artigo
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