Effect of graded doses of nicotine on ovarian and uterine activities in albino rats.
Indian J Exp Biol
;
1999 Feb; 37(2): 184-6
Artigo
em Inglês
| IMSEAR
| ID: sea-61902
ABSTRACT
Nicotine (2 and 4 mg/kg body weight, i.p.) administered to albino rats for 20 days decreased the number of healthy follicles and increased the number of regressing follicles in the ovary. Uterine weight, its diameter, thickness of myometrium and endometrium and height of epithelium were reduced. Increase in the ovarian cholesterol level and decrease in glycogen content in nicotine treated rats indicate the inhibition brought in the steroidogenesis which is dependent on pituitary gonadotrophins. Decreased protein content of the ovary and uterus may be due to their retarded growth. Reduced number of estrous cycle with prolonged metaestrus and diestrus also supports the decreased estrogen synthesis responsible for cornification of vaginal smear in nicotine treated rats.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ovário
/
Ratos
/
Útero
/
Feminino
/
Estro
/
Colesterol
/
Estrogênios
/
Glicogênio
/
Animais
/
Nicotina
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1999
Tipo de documento:
Artigo
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