Molecular basis of X-linked non-specific mental retardation.
Indian J Exp Biol
;
2004 Jun; 42(6): 549-57
Artigo
em Inglês
| IMSEAR
| ID: sea-61986
ABSTRACT
Mental retardation (MR) is a common disorder, affecting 1-3% of the total population. This condition results from failure to develop cognitive abilities and intelligence level appropriate for the age group. Mental retardation is basically a clinically as well as etiologically heterogeneous type of condition and both genetic and non-genetic factors have been found to be involved. There are more than 1000 entries in Online Mendelian Inheritance in Man (OMIM) database under the name of mental retardation. In recent years 15 genes for X linked non-specific mental retardation have been identified which provide important clues regarding molecular and cellular processes involved in signal transduction cascade in central nervous system. Recent advancements in identification and characterization of X-linked non-specific mental retardation genes have been discussed in this review. Understanding of the molecular pathways of disease causing genes would be helpful in developing effective therapeutic approaches for mental retardation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Transdução de Sinais
/
Bases de Dados como Assunto
/
Cromossomos Humanos X
/
Deficiência Intelectual Ligada ao Cromossomo X
/
Genes Dominantes
/
Aconselhamento Genético
/
Ligação Genética
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2004
Tipo de documento:
Artigo
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