Role of HLA-DR antigen on T-cell activation in visceral leishmaniasis.
Indian J Exp Biol
;
1991 Dec; 29(12): 1101-3
Artigo
em Inglês
| IMSEAR
| ID: sea-62131
ABSTRACT
Ability of peripheral blood monocytes in association with HLA-DR molecules to support T-cell activation in response to soluble Leishmania donovani antigen was investigated. Adherent cells were stained with monoclonal antibodies. The increased number of cells with DR expression was more efficient in presenting L. donovani antigen to sensitized T-cells. The results suggest that quantitative variation in monocytes with expression of DR molecules, correlates with their ability to support T-cell response to L. donovani antigen, in vitro, as assessed by migration inhibition factor (MIF). However, it is not clear whether this is due to only HLA-DR antigen on the surface or whether other factors are involved.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Ativação Linfocitária
/
Linfócitos T
/
Antígenos HLA-DR
/
Células Cultivadas
/
Leishmaniose Visceral
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1991
Tipo de documento:
Artigo
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