Dieldrin initiates apoptosis in rat thymocytes.
Indian J Exp Biol
;
2002 Oct; 40(10): 1147-50
Artigo
em Inglês
| IMSEAR
| ID: sea-62164
ABSTRACT
In vitro incubation for 6 hr to pesticide dieldrin resulted in a dose-dependent decrease of cell viability comparable to that of dexamethasone. In vivo experiments also demonstrated that dieldrin administration induced a dose-dependent thymic atrophy which appeared to be mediated by endogenous corticosteroids. Agarose gel electrophorosis analysis, revealed the generation of typical apoptotic oligosomal DNA fragmentation in presence of dieldrin. However, in response to high concentrations of pesticide, cells seemed to undergo necrosis pathway. Thus, it may be concluded that dieldrin induced apoptosis in rat thymocytes.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Timo
/
Feminino
/
Masculino
/
Ratos Wistar
/
Apoptose
/
Dieldrin
/
Eletroforese em Gel de Ágar
/
Inseticidas
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2002
Tipo de documento:
Artigo
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