Low incidence of CNS relapse with cranial radiotherapy and intrathecal methotrexate in acute lymphoblastic leukemia.
Indian Pediatr
;
1996 Jul; 33(7): 556-60
Artigo
em Inglês
| IMSEAR
| ID: sea-6223
ABSTRACT
OBJECTIVES:
To assess the incidence of isolated central nervous system (CNS) relapses in patients of acute lymphoblastic leukemia (ALL) treated with a protocol containing cranial irradiation and intrathecal methotrexate as CNS directed therapy.DESIGN:
Prospective non randomized study.SETTING:
Department of Medical Oncology, Tata Memorial Hospital.SUBJECTS:
623 children of ALL on MCP 841.METHODS:
CNS relapse was diagnosed, if upon examination of the CSF, more than 50 cells/microliter were observed, or a count of 5 cells which were unequivocally lymphoblasts.RESULTS:
The incidence of isolated CNS relapse was 1.75% with the use of this treatment. Age, sex, white blood cell count, platelet count, lactic dehydrogenase and immunophenotyping were not significantly related to isolated CNS relapse.CONCLUSION:
A low incidence of isolated CNS relapse demonstrates the adequacy of the presymptomatic CNS therapy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Sistema Nervoso Central
/
Criança
/
Pré-Escolar
/
Metotrexato
/
Irradiação Craniana
/
Adolescente
/
Infiltração Leucêmica
Tipo de estudo:
Ensaio Clínico Controlado
/
Guia de Prática Clínica
/
Estudo de incidência
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
1996
Tipo de documento:
Artigo
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