Effect of B-HT 920 on cardiotoxic effects of ouabain in guinea pigs.
Indian J Exp Biol
;
1991 Nov; 29(11): 1084-6
Artigo
em Inglês
| IMSEAR
| ID: sea-62279
ABSTRACT
Effect of B-HT 920, a selective alpha 2 adrenoceptor agonist, was studied on ouabain induced cardiac arrhythmias and cardiac arrest in guinea pigs. Ventricular premature beats, ventricular tachyarrhythmias and cardiac arrest were induced in anaesthetized guinea pigs by slow infusion of ouabain. B-HT 920 accorded significant protection to guinea pigs against ouabain induced arrhythmias. Yohimbine inhibited the antiarrhythmic effect of B-HT 920 significantly. It is concluded that the protective effect of B-HT 920 against ouabain induced cardiac arrhythmias and cardiac arrest is mediated through the stimulation of alpha 2 adrenoceptors.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ouabaína
/
Arritmias Cardíacas
/
Azepinas
/
Feminino
/
Masculino
/
Agonistas alfa-Adrenérgicos
/
Cobaias
/
Coração
/
Parada Cardíaca
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1991
Tipo de documento:
Artigo
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