Suppression of steroidogenesis in mice granulosa cells by a synthetic nonapeptide fragment of human seminal plasma inhibin.
Indian J Exp Biol
;
1991 Oct; 29(10): 897-9
Artigo
em Inglês
| IMSEAR
| ID: sea-62282
ABSTRACT
A synthetic nonapeptide, which is C-terminal sequence of 94-amino acid of prostatic inhibin peptide was tested for progesterone and estrogen secretion by mouse granulosa cell cultures. Nonapeptide suppressed the progesterone and estrogen synthesis, the magnitude of suppression was highest at 5 ng dose level for progesterone and 50 ng dose level for estradiol. The study suggests that, nonapeptide exerts its effect by impairing the binding of FSH to granulosa cell receptors.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fragmentos de Peptídeos
/
Progesterona
/
Hormônios Esteroides Gonadais
/
Feminino
/
Células Cultivadas
/
Gonadotropinas Equinas
/
Relação Dose-Resposta a Droga
/
Hormônio Foliculoestimulante
/
Células da Granulosa
/
Inibinas
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1991
Tipo de documento:
Artigo
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