Effects of short-term treatment of solasodine on cauda epididymis in dogs.
Indian J Exp Biol
;
2002 Feb; 40(2): 169-73
Artigo
em Inglês
| IMSEAR
| ID: sea-62322
ABSTRACT
Oral administration (80 mg/kg body wt/day for 30 days) of solasodine (extracted and isolated from the berries of the Solanum xanthocarpum) to intact dogs significantly decreased the epithelial cell height of cauda epididymides. The cells became atrophic and the lumen was devoid of spermatozoa. Castration followed by the adminstration of solasodine further reduced the epithelial cell height in comparison to castrated controls. Concurrent treatment of solasodine along with testosterone propionate was unable to restore the normal epithelial lumen parameters. Total protein, sialic acid, glycogen and acid phosphatase activities were significantly reduced in solasodine treated cauda epididymides. These result suggest antiandrogenic potency of solasodine.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Alcaloides de Solanáceas
/
Testosterona
/
Fatores de Tempo
/
Fosfatase Ácida
/
Peso Corporal
/
Masculino
/
Extratos Vegetais
/
Ácido N-Acetilneuramínico
/
Cães
/
Epididimo
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2002
Tipo de documento:
Artigo
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