Potentiation of immune response against malaria in immunocompromised mice through glucan as an immunoadjuvant.

ABSTRACT

Untreated mice were fully immunocompetent but their treatment with various immunosuppressors rendered them immunocompromised with respect to one or the other or both limbs of immunity. Both, humoral immune response or cell mediated immune response suppressed mice were only partially protected against the challenge with Plasmodium berghei following their immunization. Hydrocortisone treated mice, in which both types of immune responses were suppressed, were not protected against the challenge with P. berghei following their immunization. In contrast, untreated immunized mice, were fully protected against the challenge with P. berghei. The results suggest that glucan potentiated both limbs of immunity and both were involved in the host defence against malaria.