Acephate induced oxidative damage in erythrocytes.
Indian J Exp Biol
;
2002 Aug; 40(8): 963-6
Artigo
em Inglês
| IMSEAR
| ID: sea-62370
ABSTRACT
The effect of oral administration of acephate (360 mg/kg body weight), for 15 days, daily, was investigated on the erythrocytes of male rats. Activities of acetyl cholinesterase and glucose-6-phosphate dehydrogenase decreased, while those of glutathione-s-transferase and glutathione reductase increased. Decreased glutathione content and increased lipid peroxidation suggest that there was increased oxidative stress in the erythrocytes of treated animals. Increased cholesterol/phospholipid ratio in the erythrocyte membranes and morphological changes in RBCs (scanning electron microscopy studies) were observed in acephate treated animals. The results clearly suggest that acephate induced oxidative stress in erythrocytes leads to morphological changes.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Compostos Organotiofosforados
/
Fosfolipídeos
/
Acetilcolinesterase
/
Ratos
/
Masculino
/
Peroxidação de Lipídeos
/
Membrana Celular
/
Colesterol
/
Administração Oral
/
Ratos Wistar
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2002
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS