Nucleolar organizer region heteromorphism associated with trisomy-21: a risk factor for non-disjunction?
Artigo
em Inglês
| IMSEAR
| ID: sea-62648
ABSTRACT
An unusual nucleolar organizer region (double NOR) on chromosome 13 was observed in a Down syndrome child [47, XY, +21, dNOR(13)]. The variant chromosome was inherited from the mother [46, XX, dNOR(13)]. The extra chromosome 21 in the proband was maternal origin. The frequency of NOR chromosome association showed relatively high frequency in the mother and proband as compared to the controls. The result suggest that chromosome variants involving extra copies of NOR may indeed be involved in the meiotic nondisjunction of chromosome-21.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Não Disjunção Genética
/
Masculino
/
Pré-Escolar
/
Fatores de Risco
/
Síndrome de Down
/
Região Organizadora do Nucléolo
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Idioma:
Inglês
Ano de publicação:
1989
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS