Disposition of uric acid upon administration of ofloxacin alone and in combination with other anti-tuberculosis drugs.
Indian J Exp Biol
;
2004 Mar; 42(3): 323-5
Artigo
em Inglês
| IMSEAR
| ID: sea-62816
ABSTRACT
Disposition of uric acid upon administration of ofloxacin (O) alone and in combination with other anti-tuberculosis drugs, rifampicin (R), isoniazid (H) and pyrazinamide (Z) was studied. Twelve male healthy volunteers were investigated on four different occasions with the four drugs alone or in combinations. A partially balanced incomplete block design was adopted and the subjects were randomly allocated to each group. Uric acid concentration in urine samples excreted over 0-8 hr, were determined after coding the samples. There was significant decrease in the group receiving Z when compared to other groups. Though there was a decrease in uric acid excretion in the group receiving O, it was not statistically significant. Rifampicin and H seem to increase the uric acid excretion. The incidence of arthralgia was mainly due to Z and not due to either O or other drugs in the treatment of pulmonary tuberculosis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pirazinamida
/
Rifampina
/
Ácido Úrico
/
Humanos
/
Masculino
/
Ofloxacino
/
Ensaios Clínicos como Assunto
/
Adulto
/
Isoniazida
/
Antituberculosos
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2004
Tipo de documento:
Artigo
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