Effect of ATP sensitive potassium channel modifiers on antinociceptive effect of metoclopramide.
Indian J Exp Biol
;
2001 May; 39(5): 476-8
Artigo
em Inglês
| IMSEAR
| ID: sea-62878
ABSTRACT
Metoclopramide, a prokinetic drug, has been documented to produce antinociceptive response in animal models through opioid pathways. Morphine has been shown to act through ATP sensitive potassium channels (KATP) to produce antinociceptive response. However, such a possibility has not been examined for metoclopramide. The present study investigated this using pharmacological tools. Acetic acid induced abdominal constriction assay procedure was utilized to assess antinociception. The results confirmed that metoclopramide has antinociceptive response. Glibenclamide, a KATP channel blocker, pretreatment antagonized this response. Where as, in minoxidil pretreated animals, metoclopramide elicited an enhanced antinociceptive response. Glibenclamide and minoxidil, which are known KATP channel blocker and opener respectively, interfered with metoclopramide antinociception. These finding are suggestive of a role for KATP channels in metoclopramide antinociception in mice.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Medição da Dor
/
Masculino
/
Canais de Potássio
/
Trifosfato de Adenosina
/
Glibureto
/
Bloqueadores dos Canais de Potássio
/
Interações Medicamentosas
/
Analgésicos
/
Animais
/
Metoclopramida
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2001
Tipo de documento:
Artigo
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