Radioprotective efficacy of HT + AET in encapsulated form.
Indian J Exp Biol
;
1996 May; 34(5): 403-7
Artigo
em Inglês
| IMSEAR
| ID: sea-62888
ABSTRACT
Entrapment of 5-hydroxyl-L-tryptophan (HT) in erythrocyte ghost prepared by hypotonic method and high voltage electric discharge method are nearly same. Release of HT with beta-aminoethylisothiuronium bromide hydrobromide (HT + AET) in in vitro system is rapid but only a portion of the entrapped amount is released. Release of HT + AET in serum marginally increases at 2 hr. Compared to release in in vitro medium the release in serum is less. Survival studies with Swiss albino mice indicates that compared to HT alone, the combination of HT + AET shows about 9 times percentage survival. The same combination in the encapsulated form show comparable percentage survival though the amount needed is 1/200th times compared to free form.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Coelhos
/
Protetores contra Radiação
/
Masculino
/
Serotonina
/
Beta-Aminoetil Isotioureia
/
Composição de Medicamentos
/
Eletricidade
/
Membrana Eritrocítica
/
Animais
/
Camundongos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1996
Tipo de documento:
Artigo
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