In vivo induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) by lynestrenol.
Indian J Exp Biol
;
2005 Mar; 43(3): 291-3
Artigo
em Inglês
| IMSEAR
| ID: sea-62942
ABSTRACT
Genotoxicity study of synthetic progestin lynestrenol, was carried out on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Lynestrenol was studied at three different doses (6.87, 13.75 and 27.50 mg/kg body wt.). SCE and CA increased significantly as compared to normal control when treated with lynestrenol at 13.75 and 27.50 mg/kg body wt. The present results suggest that lynestrenol has both a genotoxic and cytotoxic effects in mouse bone marrow cells.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Troca de Cromátide Irmã
/
Peso Corporal
/
Dano ao DNA
/
Feminino
/
Células da Medula Óssea
/
Aberrações Cromossômicas
/
Anticoncepcionais Orais Sintéticos
/
Linestrenol
/
Animais
/
Camundongos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2005
Tipo de documento:
Artigo
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