Quantitative assessment of amphetamine induced behavioural changes in rhesus monkeys, Macaca mulatta.
Indian J Exp Biol
;
1995 Dec; 33(12): 980-2
Artigo
em Inglês
| IMSEAR
| ID: sea-62956
ABSTRACT
Graded dose of amphetamine (AMP; 1-4 mg/kg, im) induced suppression of approach, contact, body jerk, grooming and food forage, hypervigilance (checking), stereotyped behaviour and oral hyperkinesia in rhesus monkeys. Pretreatment with haloperidol--a dopamine receptor blocking agent (0.04 mg/kg, im)--significantly suppressed the AMP induced hypervigilance, stereotypy and oral hyperkinesia but was unable to reverse other AMP induced behavioural effects in the monkeys. Haloperidol (0.01-0.04 mg/kg, im) per se produced decrease in social and solitary behaviour and marked cataleptic posture. The results suggest that dopamine may be playing an important role in the mediation of many AMP induced behavioural changes in primates.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Comportamento Animal
/
Feminino
/
Masculino
/
Estudos de Avaliação como Assunto
/
Anfetamina
/
Animais
/
Macaca mulatta
Tipo de estudo:
Estudo diagnóstico
/
Estudos de avaliação
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1995
Tipo de documento:
Artigo
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