Suitability of limited sampling strategy to cyclosporine A oral formulation.
Indian J Exp Biol
;
2000 Aug; 38(8): 824-6
Artigo
em Inglês
| IMSEAR
| ID: sea-62979
ABSTRACT
Therapeutic drug monitoring of cyclosporine A in renal transplant patients is normally performed by measuring pre-dose trough levels or doing area under the curve profiles from all possible sampling points. On the basis of good correlation between predicted area under the curve from limited sampling points and actual area under the curve (literature survey), a limited sampling strategy at 1, 3 and 5 hr was used and extended this strategy as a criteria for pilot evaluation of modified cyclosporine A formulations. Hemodialysis patients served as subjects for the study. Panimun Bioral was used as a test formulation while Sandimmun Neoral as standard reference. The study revealed that both formulations had similar restricted AUC0-5h profiles.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Administração Oral
/
Diálise Renal
/
Monitoramento de Medicamentos
/
Ciclosporina
/
Área Sob a Curva
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2000
Tipo de documento:
Artigo
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