Control of zoopathogenic fungi in vitro by polyamine biosynthesis inhibitors.
Indian J Exp Biol
;
1992 Jun; 30(6): 538-40
Artigo
em Inglês
| IMSEAR
| ID: sea-63137
ABSTRACT
Effect of inhibitors of polyamine (PA) biosynthesis, alpha-difluoromethylornithine (DFMO), methylglyoxal bis (guanylhydrazone)--MGBG and bis (cyclohexylammonium) sulphate (BCHA) on mycelial growth of three clinically important fungi-Trichophyton mentagrophytes, Microsporum gypseum and Aspergillus flavus was examined in vitro. All inhibitors at concentrations 1 to 50 mM produced greater inhibition of mycelial growth in all fungi tested in a dose-dependent manner. MGBG was the most effective inhibitor, and T. mentagrophytes was the most sensitive fungus to all inhibitors followed by M. gypseum and A. flavus. The results suggested that control of fungal diseases in animals and human beings with specific inhibitors of PA biosynthesis is possible.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Poliaminas
/
Aspergillus flavus
/
Trichophyton
/
Eflornitina
/
Glutaratos
/
Microsporum
/
Mitoguazona
/
Antifúngicos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1992
Tipo de documento:
Artigo
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