Inhibition of albumin denaturation and anti-inflammatory activity of acetamido [(phenyl-4'-yl)-oxymethyl)]2-(p-substituted phenylamino)-1,2,4-triazoles and -1,3,4-thiadiazoles.
Indian J Exp Biol
;
1993 Apr; 31(4): 395-6
Artigo
em Inglês
| IMSEAR
| ID: sea-63212
ABSTRACT
Acetamido [(phenyl-4'-yl)-oxymethyl)]-2-(p-substituted-phenylamino)-1,2,4-tr iazoles (4a-4d) and 1,3,4-thiadiazoles (5a-5d) inhibited the thermal denaturation of bovine serum albumin. As protein denaturation is implicated in inflammation, some compounds which showed good inhibition of denaturation were tested in vivo for anti-inflammatory activity by carrageenan induced edema in the rat paw. Although there was no complete correlation, compounds which showed good inhibition of denaturation also showed significant anti-inflammatory activity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Desnaturação Proteica
/
Ratos
/
Tiadiazóis
/
Triazóis
/
Feminino
/
Masculino
/
Soroalbumina Bovina
/
Inflamação
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1993
Tipo de documento:
Artigo
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