Study of activating and conjugating enzymes of drug metabolism in zinc deficiency.
Indian J Exp Biol
;
1989 Sep; 27(9): 799-801
Artigo
em Inglês
| IMSEAR
| ID: sea-63251
ABSTRACT
A study was undertaken to investigate the activities of certain enzymes of drug metabolism in zinc deficiency. For this purpose, an experimental model for zinc deficiency was produced in a NIN/Wistar strain of rats by feeding an egg albumin-starch based diet. Of the two enzymes of Phase I pathway of drug metabolism studied, Benz (alpha) pyrene hydroxylase was altered in zinc deficiency and food restriction; the other one microsomal epoxide hydrolase was unchanged. The activity of glutathione-S-transferase, a key enzyme in conjugation reaction was significantly lowered in zinc deficiency as well as food restriction. These alterations in the activities of xenobiotic metabolising enzymes are discussed with reference to toxicity manifestation in zinc deficiency.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Ratos Endogâmicos
/
Zinco
/
Hidrocarboneto de Aril Hidroxilases
/
Benzopireno Hidroxilase
/
Epóxido Hidrolases
/
Glutationa Transferase
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1989
Tipo de documento:
Artigo
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