Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity.
Indian J Exp Biol
;
1996 Sep; 34(9): 845-7
Artigo
em Inglês
| IMSEAR
| ID: sea-63320
ABSTRACT
Whole body irradiation of rats (10 Gy as five fractions) found to produce lung fibrosis within 2 months as seen from increased lung collagen hydroxyproline and histopathology. Oral administration of antioxidants curcumin, ellagic acid, bixin and alpha-tocopherol at a concentration 200 mumole/kg body weight significantly reduced the lung collagen hydroxyproline in these animals. In serum and liver lipid peroxidation which were found to be increased by irradiation was reduced significantly by antioxidant treatment. The liver superoxide dismutase and glutathione peroxidase activity were also found to be increased and catalase activity decreased in irradiated control. Superoxide dismutase activity reduced significantly by antioxidant treatment while catalase activity was found to be increased with alpha-tocopherol treatment. The increased frequency of micronucleated polychromatic erythrocytes after whole body irradiation of mice was found to be significantly reduced with antioxidants.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fibrose Pulmonar
/
Lesões Experimentais por Radiação
/
Protetores contra Radiação
/
Ratos
/
Masculino
/
Peroxidação de Lipídeos
/
Carotenoides
/
Ratos Wistar
/
Curcumina
/
Ácido Elágico
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1996
Tipo de documento:
Artigo
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