Role of macrophage-colony stimulating factor and osteoclast differentiation factor in osteoclastogenesis of bone marrow derived stem cells.
Indian J Exp Biol
;
2002 Sep; 40(9): 995-1000
Artigo
em Inglês
| IMSEAR
| ID: sea-63409
ABSTRACT
Macrophage colony stimulating factor (M-CSF) and osteoclast differentiation factor (ODF) regulate osteoclastogenesis in vivo. Regulation of osteoclast development in vitro by these cytokines has been reported in the present study. Simultaneous addition of ODF and M-CSF during initiation of bone marrow culture inhibited osteoclastogenesis. However, delayed addition of ODF (three days after initiation of the culture) resulted in dramatic increase in phenotypically and functionally mature osteoclast cells. Delayed addition of ODF beyond day three decreased osteoclastogenesis. Further, removal of M-CSF as early as day three inhibited ODF-induced osteoclastogenesis. These studies provided evidence for the importance of co-ordinated regulation of osteoclastogenesis by M-CSF and ODF.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Osteoclastos
/
Osteogênese
/
Tartaratos
/
Fatores de Tempo
/
Fosfatase Ácida
/
Medula Óssea
/
Proteínas Recombinantes
/
Células-Tronco Hematopoéticas
/
Glicoproteínas de Membrana
/
Proteínas de Transporte
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2002
Tipo de documento:
Artigo
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