Anti-secretagogue effect of lithium on isolated rat islets of Langerhans.
Indian J Exp Biol
;
1989 Feb; 27(2): 163-5
Artigo
em Inglês
| IMSEAR
| ID: sea-63410
ABSTRACT
Administration of lithium carbonate solution (50 mg/kg, po, twice daily) to Charles Foster male albino rats for 45 consecutive days caused an intolerance to oral glucose. Inhibition in (pro)insulin biosynthesis followed by a significant fall in immunoreactive insulin release was seen in islets isolated from identically treated rats. As the activities of acid phosphatase and cathepsin B were unaltered, it is possible that the anti-secretagogue effect is sequential to inhibition of (pro)insulin biosynthesis by lithium.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Masculino
/
Ilhotas Pancreáticas
/
Insulina
/
Lítio
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1989
Tipo de documento:
Artigo
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