Synthetic peptides: a modern approach to vaccination.
Indian J Exp Biol
;
1998 Sep; 36(9): 849-61
Artigo
em Inglês
| IMSEAR
| ID: sea-63433
ABSTRACT
For induction of humoral or cell-mediated immunity, development of synthetic peptide vaccines present a novel approach and a better alternative to conventional vaccines. Construction of synthetic peptides that mimic antigenic sites is the basis of this approach. In this article various methodologies involved in the peptide synthesis are discussed. This is followed by a discussion on the strategies involved in rendering poor or non-immunogenic peptides immunogenic. These include coupling to large carrier proteins, polymeric presentation and incorporation of an identified Th cell epitope into the peptide.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Peptídeos
/
Humanos
/
Vacinas Sintéticas
/
Linfócitos B
/
Linfócitos T
/
Vacinação
/
Antígenos de Histocompatibilidade
/
Animais
/
Métodos
/
Epitopos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1998
Tipo de documento:
Artigo
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