Pegylated interferon alfa 2b and oral ribavirin in patients with HCV-related cirrhosis.
Artigo
em Inglês
| IMSEAR
| ID: sea-63519
ABSTRACT
BACKGROUND:
The treatment of hepatitis C virus (HCV)-related cirrhosis is difficult due to high frequency of adverse effects. We retrospectively reviewed the case records of patients with HCV cirrhosis to evaluate the efficacy and tolerability of pegylated (peg) interferon and ribavirin treatment in these patients.METHODS:
Medical records of 28 patients with HCV-related compensated cirrhosis were reviewed. The treatment protocol was a combination therapy of peg interferon alfa-2b (1 microg/Kg/week) plus oral ribavirin (10-12 mg/Kg/day). Primary endpoint was sustained virological response, with additional endpoints of drug tolerance, clinical or biochemical worsening and death.RESULTS:
End-of-treatment virlogic response was seen in 24 of 28 patients (85%) and sustained virologic response in 15 of 28 (53%) patients. Biochemical end-of-treatment response and sustained response were seen in 20 and 16 patients (71% and 57%), respectively. Treatment had to be stopped in 3 patients due to decompensation of liver status in two and drug intolerance in one, while dose modification was required in two patients.CONCLUSIONS:
Combination therapy with peg interferon plus ribavirin seems effective in patients with liver cirrhosis. High relapse rate, poor biochemical recovery and possibility of decompensation are issues that need to be kept in mind.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Antivirais
/
Ribavirina
/
Feminino
/
Humanos
/
Masculino
/
RNA Viral
/
Administração Oral
/
Estudos Retrospectivos
/
Resultado do Tratamento
/
Interferon-alfa
Tipo de estudo:
Guia de Prática Clínica
/
Estudo observacional
Idioma:
Inglês
Ano de publicação:
2006
Tipo de documento:
Artigo
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