Multidrug resistance 1 gene expression in Indian patients with gastric carcinoma.
Artigo
em Inglês
| IMSEAR
| ID: sea-63780
ABSTRACT
BACKGROUND:
Gastric carcinoma is frequently refractory to chemotherapy. The multidrug resistance 1 gene (MDR1) encodes for a protein (p-glycoprotein) that functions as a drug efflux pump and thus contributes to resistance to chemotherapeutic agents.METHODS:
We studied gastric tissues from 28 patients with gastric cancer for MDR1 expression, using immunohistochemistry.RESULTS:
Sixteen (57%) of 28 cases showed MDR1 expression. Sections of normal mucosa away from the tumor showed perinuclear staining for MDR1 in surface epithelial cells, whereas tumor cells showed diffuse cytoplasmic positivity.CONCLUSIONS:
Over one half of gastric carcinoma specimens at our center show MDR1 gene expression.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Neoplasias Gástricas
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Imuno-Histoquímica
/
Expressão Gênica
/
Estudos Soroepidemiológicos
/
Genes MDR
/
Índia
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2003
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS