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14C-urea breath test for assessment of gastric Helicobacter pylori colonization and eradication.
Artigo em Inglês | IMSEAR | ID: sea-63974
ABSTRACT
BACKGROUND AND

OBJECTIVE:

Urea breath test (UBT) is a reliable noninvasive technique for detecting gastric Helicobacter pylori colonization. 14C isotope-based test requires simple equipment and is inexpensive. We studied the utility of 14C-UBT in diagnosis of gastric H. pylori infection.

METHODS:

Presence of H. pylori was studied using antral histology and culture in patients with rapid urease test (RUT)-positive peptic ulcer. 14C-UBT was performed using a 185-kBq dose. Radioactivity in 15-min breath samples was measured using a beta-scintillation counter and result expressed as % dose recovered/mmol CO2. H. pylori was considered positive when any two tests were positive. All tests were repeated one month after completion of H. pylori eradication therapy.

RESULTS:

Among 41 patients (duodenal ulcer 36, gastric ulcer 5), H. pylori was detected by histology in 23 (56%) and by culture in 27 (66%). Overall, H. pylori was detected in 28 (68%) patients. Follow-up assessment was possible in 28 patients 26 cleared the infection (all three tests negative). Mean 14C recovery values at 15 minutes associated with H. pylori-positive status were significantly higher (12.3 [SD 6.8] x 10(-3); n=30; p<0.001) than those associated with H. pylori-negative status (2.1 [0.9] x 10(-3); n=26). Using receiver-operating-characteristic analysis of 15-minute 14C recovery values, a cut-off of 6.5x10(-3) gave the best separation of H. pylori-positive and -negative cases. 14C-UBT had 93% sensitivity, 96% specificity and 95% accuracy.

CONCLUSION:

14C-UBT appears to be a reliable noninvasive test for diagnosis of H. pylori infection.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Úlcera Péptica / Ureia / Testes Respiratórios / Feminino / Humanos / Masculino / Radioisótopos de Carbono / Valor Preditivo dos Testes / Curva ROC / Seguimentos Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Idioma: Inglês Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Úlcera Péptica / Ureia / Testes Respiratórios / Feminino / Humanos / Masculino / Radioisótopos de Carbono / Valor Preditivo dos Testes / Curva ROC / Seguimentos Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Idioma: Inglês Ano de publicação: 2001 Tipo de documento: Artigo