Submucosal hypoganglionosis causing chronic idiopathic intestinal pseudo-obstruction.
Artigo
em Inglês
| IMSEAR
| ID: sea-64095
ABSTRACT
A 39-year-old woman presented with recurrent symptoms suggestive of intestinal obstruction. She was put on total parenteral nutrition (TPN) and consequently developed sepsis and endocarditis. TPN was stopped and a venting enterostomy was performed. Biopsies of mucosa and submucosa were taken at surgery; immunohistochemistry for neuronal proteins, protein gene product 9.5 (PGP 9.5) and the glial S-100-protein was done. Many enlarged nerve fiber strands were found in the submucosa. Few small ganglia containing a small number of nerve cells could be observed, suggesting hypoganglionosis. This patient with chronic idiopathic intestinal pseudoobstruction of neurogenic type had a defect in the submucous plexus, whereas visceral neuropathies are usually characterized by defects of the myenteric plexus with normal submucous plexus.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Plexo Submucoso
/
Pseudo-Obstrução Intestinal
/
Feminino
/
Humanos
/
Doença Crônica
/
Adulto
/
Doença de Hirschsprung
/
Íleo
Idioma:
Inglês
Ano de publicação:
2002
Tipo de documento:
Artigo
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