Serum and tissue glycoconjugates, digoxin and magnesium levels in chronic calcific pancreatitis.
Artigo
em Inglês
| IMSEAR
| ID: sea-64165
ABSTRACT
BACKGROUND:
Endogenous or exogenous digoxin can lead to membrane Na+,K+-ATPase inhibition and hypomagnesemia. Low magnesium levels can lead to increased glycosaminoglycans (GAG) concentration in many organs.Aim:
To measure the serum levels of pancreatic GAG and glycoproteins, two major components of the extracellular matrix, in patients with chronic calcific pancreatitis (CCP). Serum levels of magnesium and digoxin were also assessed.METHODS:
Patients with CCP and age- and sex-matched healthy control subjects (15 each) were studied. Serum GAG, Mg and digoxin levels were measured. RBC membrane Na+,K+-ATPase activity was also assessed. Pancreatic tissue obtained at autopsy from seven patients with CCP and sex- and age-matched healthy subjects who had died in accidents were also tested for GAG and glycoproteins.RESULTS:
Total GAG levels were significantly increased in the serum and pancreas of patients with CCP. This was associated with lower serum Mg levels, increased serum digoxin levels and decreased RBC membrane Na+,K+-ATPase activity.CONCLUSION:
Exogenous or endogenous digoxin-induced hypomagnesemia and the consequent altered glycoconjugate metabolism may be important in the pathogenesis of CCP.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pancreatite
/
Valores de Referência
/
Índice de Gravidade de Doença
/
Feminino
/
Humanos
/
Masculino
/
Calcinose
/
Glicoconjugados
/
Biomarcadores
/
Estudos de Casos e Controles
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Fatores de risco
Idioma:
Inglês
Ano de publicação:
2001
Tipo de documento:
Artigo
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