Tumor necrosis factor-alpha gene promoter polymorphism in Iranian patients with chronic hepatitis B.
Artigo
em Inglês
| IMSEAR
| ID: sea-64298
ABSTRACT
BACKGROUND:
Clearance of hepatitis B virus (HBV) infection requires a good host immune response. Cytokines like tumor necrosis factor-alpha (TNF- alpha) may play a role in such immune response. Genetic changes in TNF-a gene promoter region are known to influence TNF- alpha expression. We therefore studied the role of one such mutation in chronic HBV infection.METHODS:
Presence of -308 G/A polymorphism in the promoter region of TNF- alpha gene was looked for in 100 patients with chronic HBV infection, 91 subjects with spontaneously recovered HBV infection and 89 healthy controls, using a PCR-RFLP method.RESULTS:
Variant alleles (A/A or A/G) were found in 22 of 100 (22%) patients with chronic HBV infection, 21 of 91 (23%) subjects with spontaneous HBV clearance and 14 of 89 (15.7%) control subjects (p=ns for inter-group comparisons).CONCLUSION:
TNF- alpha promoter polymorphism -308A is common in Iranian population, but has no association with development of chronic HBV infection.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Polimorfismo Genético
/
Humanos
/
Distribuição de Qui-Quadrado
/
Regiões Promotoras Genéticas
/
Fator de Necrose Tumoral alfa
/
Hepatite B Crônica
/
Alelos
/
Frequência do Gene
/
Irã (Geográfico)
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2006
Tipo de documento:
Artigo
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