Your browser doesn't support javascript.
loading
Oxidative stress in gastric mucosa in Helicobacter pylori infection.
Artigo em Inglês | IMSEAR | ID: sea-64316
ABSTRACT

BACKGROUND:

Infection with Helicobacter pylori is believed to be associated with generation of reactive oxygen molecules which leads to oxidative stress in the gastric mucosa; but the relation between oxidative stress and gastrointestinal mucosal damage has not been documented.

AIM:

To look for evidence of oxidative stress and lipid peroxidation in the gastric mucosa in H. pylori-associated peptic ulcer.

METHODS:

34 duodenal ulcer (DU) patients with H. pylori infection, 14 DU patients without H. pylori infection and 10 healthy subjects without H. pylori infection were studied. H. pylori infection was diagnosed by histology and rapid urease test on endoscopic biopsies from the gastric body and antrum. Reduced glutathione (GSH) and malondialdehyde (MDA) content were measured in biopsies taken from the gastric antrum. Statistical analysis was done using Student's t test.

RESULTS:

Tissue levels of GSH were significantly lower (91.7 [35.4] nmole/100 mg versus 147.3 [41.2] nmole/100 mg; p < 0.001) and MDA higher (163.0 [83.4] nmole/100 mg versus 109.2 [51.3] nmole/100 mg; p < 0.01) in patients with DU associated with H. pylori infection as compared to those without H. pylori infection. GSH levels were significantly lower and MDA levels higher in DU patients with or without H. pylori infection as compared to control subjects. Serum MDA levels in DU patients with H. pylori infection were also significantly higher than in patients without H. pylori infection.

CONCLUSION:

Depletion of gastric mucosal glutathione in H. pylori-infected DU patients may be due to failure of the antioxidant defense system. Failure of the glutathione-dependent defense system results in accumulation of free radicals which can initiate membrane damage by lipid peroxidation.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Feminino / Humanos / Masculino / Peroxidação de Lipídeos / Estudos de Casos e Controles / Helicobacter pylori / Infecções por Helicobacter / Estresse Oxidativo / Adulto / Mucosa Gástrica Tipo de estudo: Estudo observacional / Fatores de risco Idioma: Inglês Ano de publicação: 2000 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Feminino / Humanos / Masculino / Peroxidação de Lipídeos / Estudos de Casos e Controles / Helicobacter pylori / Infecções por Helicobacter / Estresse Oxidativo / Adulto / Mucosa Gástrica Tipo de estudo: Estudo observacional / Fatores de risco Idioma: Inglês Ano de publicação: 2000 Tipo de documento: Artigo