Liver function and plasma protein metabolism in rodent model of filariasis.
Artigo
em Inglês
| IMSEAR
| ID: sea-64551
ABSTRACT
Rodent model of filariasis was developed by infecting Wistar rats with Litomosoides carinii. Liver function tests, plasma protein concentrations, and synthesis rates of liver-formed proteins were estimated in these rats at 63 and 90 days post-infection. At 63 days post-infection, aspartate aminotransferase and alkaline phosphatase were significantly increased. Alanine aminotransferase, plasma total proteins and plasma albumin were in the normal range. However, at 90 days post-infection all these parameters were affected, reflecting progressive liver involvement. Hypoalbuminemia at 90 days post-infection did not appear to be due to decreased synthesis rate, indicating higher catabolism and/or altered distribution in pools.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Ratos Endogâmicos
/
Masculino
/
Proteínas Sanguíneas
/
Arvicolinae
/
Filariose
/
Fígado
/
Hepatopatias Parasitárias
/
Animais
Idioma:
Inglês
Ano de publicação:
1989
Tipo de documento:
Artigo
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