TTV infection in children with and without liver disease.
Artigo
em Inglês
| IMSEAR
| ID: sea-64681
ABSTRACT
BACKGROUND:
TTV DNA has been reported in patients with a broad spectrum of hepatic disorders as well as in healthy people.AIM:
To clarify the role of TTV in children with liver disease and in healthy children.METHODS:
Degenerate primers designed to amplify a target sequence from the ORF 1 region of TTV genome were used for nested PCR, to detect TTV DNA in sera.RESULTS:
TTV was detected in 3 of 18 children with chronic hepatitis B (16.7%), 2 of 17 hepatitis B carriers (11.8%), 2 of 17 children with cryptogenic chronic liver disease (11.8%), and 1 of 40 (2.5%) children without liver disease. The infection rate was similar among the various study groups and in the various age groups. There was no difference between TTV positive and negative children in respect to gender, history of surgery, parenteral treatment, transfusion of blood and blood products, presence of hepatomegaly, splenomegaly, jaundice, and transaminase values.CONCLUSION:
TTV does not seem to have an etiologic role in cryptogenic liver disease in children and does not seem to influence the clinical course of liver disease.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prognóstico
/
Valores de Referência
/
Turquia
/
Índice de Gravidade de Doença
/
Feminino
/
Humanos
/
Masculino
/
DNA Viral
/
Estudos de Casos e Controles
/
Criança
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2004
Tipo de documento:
Artigo
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