Your browser doesn't support javascript.
loading
Hemodynamic effect of spironolactone in liver cirrhosis and propranolol-resistant portal hypertension.
Artigo em Inglês | IMSEAR | ID: sea-64748
ABSTRACT

OBJECTIVE:

In a proportion of patients with liver cirrhosis, portal pressure does not decrease adequately with propranolol. These patients may benefit from another drug that may reduce portal pressure. We evaluated the role of spironolactone, alone or with propranolol, in such patients.

METHODS:

Patients with cirrhosis, with or without ascites, with esophageal varices and with hepatic venous pressure gradient exceeding 12 mmHg, which did not show a 20% reduction after an 80-mg oral dose of propranolol, were studied. They were allocated to receive spironolactone 100 mg orally once daily either alone (group 1, n=10) or with propranolol 40 mg orally twice daily (group 2, n=10), for 7 days, after which the hemodynamic study was repeated.

RESULTS:

Hepatic venous pressure gradient decreased in those receiving spironolactone and propranolol (p=0.007); 5 patients in group 1 and 7 in group 2 showed a reduction in hepatic venous pressure gradient by more than 20%. However, the reduction produced by spironolactone alone (20.5 [31.3]%) was not significantly different from that produced by combination therapy (30.3 [25.9]%; p=0.46).

CONCLUSION:

Spironolactone in combination with propranolol achieves adequate reduction (> or = 20%) in hepatic venous pressure gradient in propranolol-resistant portal hypertension in patients with liver cirrhosis. Spironolactone alone was also effective in some patients.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Sistema Porta / Propranolol / Espironolactona / Feminino / Humanos / Masculino / Varizes Esofágicas e Gástricas / Antagonistas Adrenérgicos beta / Adulto / Diuréticos Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Ano de publicação: 2002 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Sistema Porta / Propranolol / Espironolactona / Feminino / Humanos / Masculino / Varizes Esofágicas e Gástricas / Antagonistas Adrenérgicos beta / Adulto / Diuréticos Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Ano de publicação: 2002 Tipo de documento: Artigo