Alpha-1 antitrypsin deficiency among Indian children with liver disorders.
Artigo
em Inglês
| IMSEAR
| ID: sea-65050
ABSTRACT
AIMS:
To determine the frequency of alpha-1 antitrypsin (AAT) deficiency in children with chronic liver disease (CLD) and neonatal cholestasis syndrome (NCS).METHODS:
All children with NCS (n=23) or CLD (n=35) attending the Pediatric Gastroenterology Clinic between November 2003 and July 2005 were screened for AAT deficiency using phenotyping through isoelectric focusing of plasma.RESULTS:
Of the 58 children studied, 57 had normal PiMM phenotype. One child with CLD had the M1E type of normal variant. None of the patients had the abnormal phenotype PiZZ.CONCLUSION:
AAT deficiency is infrequent among children with CLD and NCS in our region.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fenótipo
/
Tempo de Protrombina
/
Humanos
/
Ceruloplasmina
/
Recém-Nascido
/
Criança
/
Pré-Escolar
/
Colestase
/
Deficiência de alfa 1-Antitripsina
/
Alanina Transaminase
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2006
Tipo de documento:
Artigo
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