Assessment of insulin resistance and effect of metformin in nonalcoholic steatohepatitis--a preliminary report.
Artigo
em Inglês
| IMSEAR
| ID: sea-65242
ABSTRACT
INTRODUCTION:
Insulin resistance plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Insulin-sensitizing drugs like metformin may have a role in the treatment of this disease.OBJECTIVE:
To determine insulin resistance and the role of metformin in the treatment of NASH.METHODS:
We prospectively studied 25 patients with NASH over a period of one and a half years. In addition to clinicopathological profile, we studied the insulin resistance by insulin tolerance test in 10 of them; seven of them, who did not respond to 3 months of low-calorie, low-fat diet, exercise, weight reduction and ursodeoxycholic acid (UDCA), were treated with metformin for six months. Results were compared with control groups.RESULTS:
All 10 patients with NASH tested had low insulin sensitivity; there was significant difference in the rate constant for insulin sensitivity (Kitt) between patients with NASH and normal volunteers. Thirteen (52%) patients responded to dietary restriction, exercise, weight reduction and UDCA. Four of 7 patients treated with metformin had normalization of ALT.CONCLUSION:
Patients with NASH have insulin resistance. Metformin may have a role in the treatment of these patients.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Resistência à Insulina
/
Adulto
/
Alanina Transaminase
/
Hepatite
/
Hipoglicemiantes
/
Fígado
/
Metformina
Idioma:
Inglês
Ano de publicação:
2004
Tipo de documento:
Artigo
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