Correlation of serotonin and monoamine oxidase levels with anxiety level in diarrhea-predominant irritable bowel syndrome.
Artigo
em Inglês
| IMSEAR
| ID: sea-65285
ABSTRACT
BACKGROUND:
Irritable bowel syndrome (IBS) is generally considered to have a psychogenic component in its physiopathology.AIM:
To study the role of serotonin (5-hydroxytryptamine; 5-HT), monoamine oxidase (MAO) and anxiety, and to elucidate the relationship between these in patients with diarrhea-predominant IBS.METHODS:
5-HT and MAO activity and anxiety levels were studied in 20 healthy volunteers (aged 18-25 years; all men) and 57 patients with diarrhea-predominant IBS (30-60 years; all men).RESULTS:
The concentrations of 5-HT (0.3 [0.04] microg/ mL) and MAO (15.5 [3.2] U/mL), and the anxiety level score (14.4 [2.9]) were significantly higher (p < 0.001) in patients than in healthy volunteers (0.1 [0.02], 6.4 [1.4] and 3.4 [1.2], respectively). These parameters correlated with each other in both patients and volunteers.CONCLUSIONS:
Elevated 5-HT and MAO activity and anxiety may play a role in patients with diarrhea-predominant IBS.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ansiedade
/
Humanos
/
Masculino
/
Biomarcadores
/
Serotonina
/
Estatística como Assunto
/
Adolescente
/
Doenças Funcionais do Colo
/
Adulto
/
Diarreia
Tipo de estudo:
Estudos de avaliação
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2003
Tipo de documento:
Artigo
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