Induction of oxidative stress in antitubercular drug-induced hepatotoxicity.
Artigo
em Inglês
| IMSEAR
| ID: sea-65412
ABSTRACT
BACKGROUND AND AIM:
Oxidative stress could play a role in the pathogenesis of antitubercular drug (ATD)-induced hepatotoxicity. We therefore studied the plasma level of reduced glutathione (GSH) and malondialdehyde (MDA) in patients with ATD-induced hepatotoxicity (cases), ATD-treated controls (disease controls) and in healthy volunteers.METHODS:
This study was carried out in a case-control design. Twenty-one cases, 21 age- and sex-matched disease controls, and 10 healthy volunteers were enrolled. Plasma levels of GSH and MDA were measured.RESULTS:
Plasma levels of GSH (median [range] 11.5 [6.2-21.2] mmol/dL) and MDA (1390 [560-2310] nmol/dL) of cases were significantly different (p<0.01) from GSH (18.4 [10.5-24.4]) and MDA (290 [240-550]) of disease controls. Further, plasma GSH and MDA levels of both the ATD-treated groups were different from those in healthy controls.CONCLUSION:
Lower levels of plasma GSH and higher levels of MDA may be due to oxidative stress resulting from ATD therapy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tuberculose
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Estudos de Casos e Controles
/
Modelos Lineares
/
Estudos Prospectivos
/
Estatísticas não Paramétricas
/
Estresse Oxidativo
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Ano de publicação:
2001
Tipo de documento:
Artigo
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