Role of ketamine in convulsions.
Indian J Med Sci
;
1999 Nov; 53(11): 475-80
Artigo
em Inglês
| IMSEAR
| ID: sea-66866
ABSTRACT
It can be concluded from the present study that ketamine showed dose-dependent anticonvulsant effect on MES in mice. It is presumed that this anticonvulsant effect of ketamine could be due to blockade of excitatory amino acid NMDA receptors. It was potentiated by anticonvulsants like diazepam and DPH but was found to be insensitive to naloxone. These findings suggest the involvement of NMDA receptors and their antagonists in epilepsy. Ketamine thus can be given as add-on therapy in refractory cases, and may prove to be useful as an anticonvulsant in future.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Masculino
/
Receptores de N-Metil-D-Aspartato
/
Antagonistas de Aminoácidos Excitatórios
/
Diazepam
/
Relação Dose-Resposta a Droga
/
Interações Medicamentosas
/
Quimioterapia Combinada
/
Eletrochoque
/
Epilepsia
Idioma:
Inglês
Revista:
Indian J Med Sci
Ano de publicação:
1999
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS